Numerous potentially functional but non-genic conserved sequences on human chromosome 21

  title={Numerous potentially functional but non-genic conserved sequences on human chromosome 21},
  author={Emmanouil T. Dermitzakis and Alexandre Reymond and Robert Lyle and Nathalie Scamuffa and Catherine Ucla and Samuel Deutsch and Brian J. Stevenson and Volker Flegel and Philipp Bucher and C. Victor Jongeneel and Stylianos E. Antonarakis},
The use of comparative genomics to infer genome function relies on the understanding of how different components of the genome change over evolutionary time. The aim of such comparative analysis is to identify conserved, functionally transcribed sequences such as protein-coding genes and non-coding RNA genes, and other functional sequences such as regulatory regions, as well as other genomic features. Here, we have compared the entire human chromosome 21 with syntenic regions of the mouse… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 28 references

A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome

Mural, J R.
Science 296, • 2002

Intra- and interspecific variation in primate gene expression patterns

W Enard
Science 296, • 2002

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