Numerous niches for hematopoietic stem cells remain empty during homeostasis.

@article{Shimoto2017NumerousNF,
  title={Numerous niches for hematopoietic stem cells remain empty during homeostasis.},
  author={Manabu Shimoto and Tatsuki Sugiyama and Takashi Nagasawa},
  journal={Blood},
  year={2017},
  volume={129 15},
  pages={2124-2131}
}
Hematopoietic stem cells (HSCs) reside in and are maintained by special microenvironments, termed niches. It is assumed that the HSC niche space remains occupied by endogenous cells and that myelosuppressive conditioning is required to achieve high levels of HSC engraftment. We herein demonstrate that upon the transplantation of very large numbers of purified HSCs into normal mice not exposed to myeloablation, donor HSCs engrafted in niches distant from filled HSC niches without replacing host… CONTINUE READING

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