Numerical validation and properties of a rapid binding approximation of a target-mediated drug disposition pharmacokinetic model

@article{Marathe2009NumericalVA,
  title={Numerical validation and properties of a rapid binding approximation of a target-mediated drug disposition pharmacokinetic model},
  author={Anshu Marathe and Wojciech Krzyzanski and Donald E Mager},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  year={2009},
  volume={36},
  pages={199-219}
}
Target mediated drug disposition (TMDD) describes the phenomenon where high affinity binding of a drug to its pharmacological target (enzymes or receptors) significantly alters the pharmacokinetic profile of the drug. A rapid binding model replaces the often inestimable binding micro-constants (k on and k off) of TMDD models with the equilibrium dissociation constant (K D) by assuming rapid binding of the drug to its target. The purpose of this study is to examine the validity of the rapid… CONTINUE READING

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