• Corpus ID: 11344555

Numerical modeling of inhomogeneous DNA replication kinetics

  title={Numerical modeling of inhomogeneous DNA replication kinetics},
  author={Michel G. Gauthier and Antoine Dub'e and John Bechhoefer},
  journal={arXiv: Quantitative Methods},
We present a calculation technique for modeling inhomogeneous DNA replication kinetics, where replication factors such as initiation rates or fork speeds can change with both position and time. We can use our model to simulate data sets obtained by molecular combing, a widely used experimental technique for probing replication. We can also infer information about the replication program by fitting our model to experimental data sets and also test the efficacy of planned experiments by fitting… 

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