Numerical investigation of dynamic microorgan devices as drug screening platforms. Part I: Macroscale modeling approach & validation.


The dynamic nature of in vitro drug metabolism models demands reliable numerical tools to determine key design parameter values towards high-fidelity cell-based platforms of in vivo drug metabolism. This paper represents the first of a two-part model-based investigation of a 3D dynamic microorgan device (DMD). The prescribed tissue model in this paper is… (More)
DOI: 10.1002/bit.25822


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