Numeric aberrations of HER-2 and chromosome 17 detected by fluorescence in situ hybridization in urine-exfoliated cells from patients with urothelial carcinoma.

@article{Inoue2004NumericAO,
  title={Numeric aberrations of HER-2 and chromosome 17 detected by fluorescence in situ hybridization in urine-exfoliated cells from patients with urothelial carcinoma.},
  author={Takamitsu Inoue and Kazunari Sato and Norihiko Tsuchiya and Shinobu Matsuura and Masahiro Iinuma and Tomonori Habuchi and Tetsuro Kato},
  journal={Urology},
  year={2004},
  volume={64 3},
  pages={
          617-21
        }
}
OBJECTIVES To elucidate the clinical significance of the HER-2 gene alterations in urine-exfoliated cells detected by fluorescence in situ hybridization (FISH) in patients with urothelial transitional cell carcinoma. METHODS The relative increase of HER-2 (RI-HER2) and gain of chromosome 17 (G-17) in urine-exfoliated cells were examined using DNA probes for HER-2 and the chromosome 17 centromere in 103 patients. In addition, FISH analysis was performed using corresponding paraffin-embedded… Expand
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