Number of prostate cancer risk alleles may identify possibly 'insignificant' disease.

@article{Helfand2010NumberOP,
  title={Number of prostate cancer risk alleles may identify possibly 'insignificant' disease.},
  author={Brian T. Helfand and Stacy L. Loeb and Donghui Kan and William J. Catalona},
  journal={BJU international},
  year={2010},
  volume={106 11},
  pages={1602-6}
}
OBJECTIVE To determine whether the cumulative effects of five prostate cancer risk alleles (three single-nucleotide polymorphisms [SNPs] on chromosome 8Q24 and two SNPs on chromosome 17a) could help to identify possibly 'insignificant' disease. MATERIALS AND METHODS We genotyped 629 men of European ancestry who underwent radical prostatectomy at our institution between 2002 and 2007. Possibly 'insignificant' CaP was defined using the Ohori criteria (organ-confined, tumour volume <0.5 mL… CONTINUE READING