Number of osteoprogenitor cells in human bone marrow markedly decreases after skeletal maturation

@article{Nishida1999NumberOO,
  title={Number of osteoprogenitor cells in human bone marrow markedly decreases after skeletal maturation},
  author={Saburo Nishida and Naoto Endo and Hiroshi Yamagiwa and Tatsuhiko Tanizawa and Hideaki Takahashi},
  journal={Journal of Bone and Mineral Metabolism},
  year={1999},
  volume={17},
  pages={171-177}
}
Pluripotent mesenchymal stem cells in bone marrow differentiate to osteoblast progenitor cells. When the bone marrow cells are cultured in vitro, they form colony-forming units-fibroblastic (CFU-Fs) with exhibiting osteoblastic features such as expression of alkaline phosphatase (ALP) and formation of calcified nodules ex vivo. This article describes the effect of growth, maturation, and aging of the skeleton on human CFU-Fs harvested from human iliac bone marrow. Human bone marrow cells were… CONTINUE READING

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