Number needed to treat in COPD: exacerbations versus pneumonias.

  title={Number needed to treat in COPD: exacerbations versus pneumonias.},
  author={Oliver N. Keene and Antonio Anzueto and Gary Thomas Ferguson and Peter M. A. Calverley},
  volume={68 9},
Number needed to treat (NNT) is an attractive concept for clinicians, but its application to a treatment that reduces the frequency of COPD exacerbations is not straightforward. Dr Suissa proposes a method for calculating the NNT based on the Kaplan–Meier curve of time to first exacerbation. This approach ignores all exacerbations beyond the first one experienced by the patient and does not appropriately reflect the benefit of a treatment that reduces multiple exacerbations in the same patient… CONTINUE READING

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Number needed to treat in COPD : exacerbations versus pneumonias

  • S Suissa
  • Thorax
  • 2013

Statistical analysis of exacerbation rates in COPD : TRISTAN and ISOLDE revisited

  • ON Keene, Calverley PMA, PW Jones
  • Eur Respir J
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