Numb is required to prevent p53-dependent senescence following skeletal muscle injury

Abstract

Regeneration relies on coordinated action of multiple cell types to reconstitute the damaged tissue. Here we inactivate the endocytic adaptor protein Numb in skeletal muscle stem cells prior to chronic or severe muscle injury in mice. We observe two types of senescence in regenerating muscle; a transient senescence in non-myogenic cells of control and Numb… (More)
DOI: 10.1038/ncomms9528

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@inproceedings{Roux2015NumbIR, title={Numb is required to prevent p53-dependent senescence following skeletal muscle injury}, author={Isabelle le Roux and Julie Konge and Laurent Le Cam and Patricia Flamant and Shahragim Tajbakhsh}, booktitle={Nature communications}, year={2015} }