Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retina.

@article{Kechad2012NumbIR,
  title={Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retina.},
  author={Amel Kechad and Christine Jolicoeur and Adele R Tufford and Pierre Mattar and Renee W Y Chow and William A. Harris and Michel Cayouette},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 48},
  pages={17197-17210}
}
In the developing nervous system, cell diversification depends on the ability of neural progenitor cells to divide asymmetrically to generate daughter cells that acquire different identities. While much work has recently focused on the mechanisms controlling self-renewing asymmetric divisions producing a differentiating daughter and a progenitor, little is known about mechanisms regulating how distinct differentiating cell types are produced at terminal divisions. Here we study the role of the… CONTINUE READING
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