Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination

Abstract

The developmental protein Numb is a major determinant of binary cell fates. It is also required for the differentiation of cerebellar granule cell progenitors (GCPs) at a stage of development responsive to the morphogenic glycoprotein Hedehog. Hedgehog signalling is crucial for the physiological maintenance and self-renewal of neural stem cells and its… (More)
DOI: 10.1038/ncb1510

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@article{Marcotullio2006NumbIA, title={Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination}, author={Lucia Di Marcotullio and Elisabetta Ferretti and A. F. G. Greco and Enrico De Smaele and Agnese Po and Maria Anna Sico and Maurizio Alimandi and Giuseppe Giannini and Marella Maroder and Isabella Screpanti and Alberto Gulino}, journal={Nature Cell Biology}, year={2006}, volume={8}, pages={1415-1423} }