Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development

@inproceedings{MartinBlanco2014NumbdependentIO,
  title={Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development},
  author={N M Martin-Blanco and Saula Checquolo and F Del Gaudio and Rocco Palermo and Giulia Franciosa and Lucia di Marcotullio and Alberto Gulino and Matilde Ca{\~n}elles and Isabella Screpanti},
  booktitle={Cell Death and Disease},
  year={2014}
}
Numb asymmetrically segregates at mitosis to control cell fate choices during development. Numb inheritance specifies progenitor over differentiated cell fates, and, paradoxically, also promotes neuronal differentiation, thus indicating that the role of Numb may change during development. Here we report that Numb nuclear localization is restricted to early thymocyte precursors, whereas timed appearance of pre-T-cell receptor (pre-TCR) and activation of protein kinase Cθ promote phosphorylation… CONTINUE READING