Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

@article{Marcotullio2011NumbAT,
  title={Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal},
  author={Lucia Di Marcotullio and Azzura Greco and Daniela Mazz{\`a} and Gianluca Canettieri and Laura Pietrosanti and P. Diane Infante and Sonia Coni and Massimo Moretti and Enrico De Smaele and Elisabetta Ferretti and Isabella Screpanti and Alberto Gulino},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={65-76}
}
Hedgehog pathway regulates tissue patterning and cell proliferation. Gli1 transcription factor is the major effector of Hedgehog signaling and its deregulation is often associated to medulloblastoma formation. Proteolytic processes represent a critical mechanism by which this pathway is turned off. Here, we characterize the regulation of an ubiquitin… CONTINUE READING