Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis.

@article{Bogdanovi2012NumbNumblOpoAC,
  title={Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis.},
  author={Ozren Bogdanovi{\'c} and Mariana Delfino-Mach{\'i}n and Mar{\'i}a Nicol{\'a}s-P{\'e}rez and Maria P. Gavilan and In{\^e}s Gago-Rodrigues and Ana Fern{\'a}ndez-Mi{\~n}{\'a}n and Concepci{\'o}n Lillo and Rosa M Rios and Joachim Wittbrodt and Juan Ram{\'o}n Martinez-Morales},
  journal={Developmental cell},
  year={2012},
  volume={23 4},
  pages={782-95}
}
Polarized trafficking of adhesion receptors plays a pivotal role in controlling cellular behavior during morphogenesis. Particularly, clathrin-dependent endocytosis of integrins has long been acknowledged as essential for cell migration. However, little is known about the contribution of integrin trafficking to epithelial tissue morphogenesis. Here we show how the transmembrane protein Opo, previously described for its essential role during optic cup folding, plays a fundamental role in this… CONTINUE READING
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