Null mutation of PCLN-1/Claudin-16 results in bovine chronic interstitial nephritis.

Abstract

Inherited chronic renal diseases are associated with failures in glomerular filtration and tubular resorption. Such failures invariably result from defects in selective filtration and absorption in surface renal epithelium. Recently, we described an autosomal recessive chronic interstitial nephritis with diffuse zonal fibrosis (CINF) in cattle. Bovine CINF… (More)

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@article{Hirano2000NullMO, title={Null mutation of PCLN-1/Claudin-16 results in bovine chronic interstitial nephritis.}, author={T Hirano and Naoya Kobayashi and Tomoo Itoh and Akiko Takasuga and Tomomi Nakamaru and S Hirotsune and Yumi Sugimoto}, journal={Genome research}, year={2000}, volume={10 5}, pages={659-63} }