Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.

@article{Qiu1995NullMO,
  title={Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain.},
  author={Mengsheng Qiu and Alexandro Bulfone and Salvador Martinez and Juanito J. Meneses and Kenji Shimamura and Roger A. Pedersen and J L Rubenstein},
  journal={Genes \& development},
  year={1995},
  volume={9 20},
  pages={
          2523-38
        }
}
Genetic analysis of the development and evolution of the vertebrate head is at a primitive stage. Many homeo box genes, including the Distal-less family, are potential regulators of head development. To determine the function of Dlx-2, we generated a null mutation in mice using gene targeting. In homozygous mutants, differentiation within the forebrain is abnormal and the fate of a subset of cranial neural crest cells is respecified. The latter causes abnormal morphogenesis of the skeletal… 

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