Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.

@article{Albert2014NullMI,
  title={Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.},
  author={Jessica S. Albert and Laura M Yerges-Armstrong and Richard B. Horenstein and Toni Pollin and Urmila Sreenivasan and Sumbul Chai and William S. Blaner and Soren Snitker and Jeffrey R. O'Connell and Da-Wei Gong and Richard J. Breyer and Alice S Ryan and John C. Mclenithan and Alan R. Shuldiner and Carole Sztalryd and Coleen M. Damcott},
  journal={The New England journal of medicine},
  year={2014},
  volume={370 24},
  pages={
          2307-2315
        }
}
BACKGROUND Lipolysis regulates energy homeostasis through the hydrolysis of intracellular triglycerides and the release of fatty acids for use as energy substrates or lipid mediators in cellular processes. Genes encoding proteins that regulate energy homeostasis through lipolysis are thus likely to play an important role in determining susceptibility to metabolic disorders. METHODS We sequenced 12 lipolytic-pathway genes in Old Order Amish participants whose fasting serum triglyceride levels… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

Complex Genetics of Type 2 Diabetes and Effect Size: What have We Learned from Isolated Populations?

  • The review of diabetic studies : RDS
  • 2015
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Energy metabolism of white adipose tissue and insulin resistance in humans.

  • European journal of clinical investigation
  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 25 REFERENCES

Adipose tissue lipolysis.

  • Current opinion in clinical nutrition and metabolic care
  • 2010

Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009