Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana.

@article{Souza1994NullMF,
  title={Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana.},
  author={Andre L. Souza and Paul A. Bates and Graham H. Coombs and Jeremy C Mottram},
  journal={Molecular and biochemical parasitology},
  year={1994},
  volume={63 2},
  pages={213-20}
}
The parasitic protozoon Leishmania mexicana possesses an abundance of developmentally regulated cathepsin L-like cysteine proteinases expressed at highest levels in amastigotes. We recently characterised lmcpa, a single-copy gene encoding one such proteinase, LmCPa, which differs from other homologues by possessing a 3-amino-acid insertion at the amino terminal of the predicted mature proteinase. To investigate the role of LmCPa in L. mexicana, we used gene-targeting of promastigotes with… CONTINUE READING

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