NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.

Abstract

The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC, NudCL2 (NudC-like protein 2), as a regulator of LIS1. NudCL2 is… (More)
DOI: 10.1073/pnas.0914307107

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@article{Yang2010NudClikeP2, title={NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.}, author={Yuehong Yang and Xiaoyi Yan and Yuqi Cai and Yiqing Lu and Jianmin Si and Tianhua Zhou}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2010}, volume={107 8}, pages={3499-504} }