Nucleus-specific differences in GABA(A)-receptor-mediated inhibition are enhanced during thalamic development.

@article{Huntsman2000NucleusspecificDI,
  title={Nucleus-specific differences in GABA(A)-receptor-mediated inhibition are enhanced during thalamic development.},
  author={Molly M. Huntsman and John R. Huguenard},
  journal={Journal of neurophysiology},
  year={2000},
  volume={83 1},
  pages={350-8}
}
Inhibitory postsynaptic currents (IPSCs) mediated by GABA(A) receptors are much slower in neurons of the thalamic reticular nucleus (RTN) versus those in the ventrobasal complex (VB) of young rats. Here we confirm and extend those findings regarding GABA(A) response heterogeneity especially in relation to development. Whole cell patch-clamp recordings were used to investigate GABA(A) spontaneous and electrically evoked IPSCs (sIPSCs/eIPSCs) in RTN and VB cells of different aged rats. Consistent… CONTINUE READING
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