Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons

@article{Yamamoto1985NucleusRD,
  title={Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons},
  author={T. Yamamoto and Asao Hirano},
  journal={Annals of Neurology},
  year={1985},
  volume={17}
}
Diffuse serotonergic fibers are presumed to project to the talencephalon from the nucleus raphe dorsalis (NRD) of the mid brain, in a manner similiar to the cholinergic projections from the nucleus basalis of Meynert (nbM) to the cerebral cortex. Neuropathological changes in both of these nuclei have been reported in Alzheimer's disease (AD). Although many morphometric studies of the nbM in AD have been documented, only one such study of the NRD has been documented, only one such study of the… 
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TLDR
It is concluded that the dysfunction and death of cholinergic neurons in the nbM is associated with extensive NFT formation, including apparently residual NFTs in loci where n bM neurons once existed; and many noncholinergic neuron and neurites in the basal forebrain show NFT and senile plaque formation.
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It is found that the inferior and superior colliculi and the autonomic, monoaminergic, cholinergic, and classical reticular nuclei were affected with varying degrees of severity and frequencies in 32 patients with Alzheimer's disease, whereas no changes were seen in the brainstems of 26 control subjects.
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References

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TLDR
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