Nucleus pulposus cell-matrix interactions with laminins.

  title={Nucleus pulposus cell-matrix interactions with laminins.},
  author={Christopher L. Gilchrist and Aubrey T. Francisco and George E. Plopper and Jun Chen and Lori A. Setton},
  journal={European cells & materials},
The cells of the nucleus pulposus (NP) region of the intervertebral disc play a critical role in this tissue's generation and maintenance, and alterations in NP cell viability, metabolism, and phenotype with aging may be key contributors to progressive disc degeneration. Relatively little is understood about the phenotype of NP cells, including their cell-matrix interactions which may modulate phenotype and survival. Our previous work has identified strong and region-specific expression of… CONTINUE READING


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