Nucleus accumbens shell and core dopamine: differential role in behavior and addiction

@article{Chiara2002NucleusAS,
  title={Nucleus accumbens shell and core dopamine: differential role in behavior and addiction},
  author={Gaetano di Chiara},
  journal={Behavioural Brain Research},
  year={2002},
  volume={137},
  pages={75-114}
}
  • G. Chiara
  • Published 2 December 2002
  • Biology, Psychology
  • Behavioural Brain Research

Reward system and addiction: what dopamine does and doesn't do.

ROLE OF DOPAMINE OF NUCLEUS ACCUMBENS IN BEHAVIORAL SENSITIZATION TO METHYLPHENIDATE

The role of dopaminergic afferents of the NAc in the behavioral sensitization elicited by chronic treatment with methylphenidate, a psychostimulant that is widely used to treat attention deficit hyperactivity disorder, is investigated and two distinct responses were seen to the acute injection of MPD.

Nucleus Accumbens Dopamine and the Regulation of Effort in Food-Seeking Behavior: Implications for Studies of Natural Motivation, Psychiatry, and Drug Abuse

Accumbens DA may be important for enabling rats to overcome behavioral constraints, such as work-related response costs, and may be critical for the behavioral organization and conditioning processes that enable animals to engage in vigorous responses, or to emit large numbers of responses in ratio schedules in the absence of primary reinforcement.

Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression

Results indicate that DA D1 and D2 receptors in the NAc shell are involved in the acquisition of morphine-induced CPP.

The role of mesoaccumbens dopamine in nicotine dependence.

  • D. Balfour
  • Biology, Psychology
    Current topics in behavioral neurosciences
  • 2015
There is abundant evidence that the dopamine (DA) neurons that project to the nucleus accumbens play a central role in neurobiological mechanisms underpinning drug dependence. This chapter considers

Reciprocal responsiveness of nucleus accumbens shell and core dopamine to food- and drug-conditioned stimuli

Drug–CSs differentially activate DA as compared to food- and drug-conditioned stimuli in shell and core and differentially affect DA response to the US in these areas and might be relevant for the role of DA in the mechanism of drug addiction.

Differential changes in signal and background firing of accumbal neurons during cocaine self-administration.

The hypothesis that the phasic firing associated with drug seeking is less sensitive than other accumbal firing to the inhibitory effect of cocaine is tested and this type of differential inhibition in signal and background firing might be expected to increase the relative influence of the drug-reward-related signals on accumbAL-related neural circuits and differentially influence susceptibility of drug- and non-drug-reWARD-related synaptic and neural responses to neuroplasticity.
...

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A motivational learning hypothesis of the role of mesolimbic dopamine in compulsive drug use

This work has shown that activation of DA transmission by conventional reinforcers is under strong inhibitory control by previous exposure to the reinforcer (habituation); this, however, is not the case with drug reinfor...

Opponent Process Model and Psychostimulant Addiction

Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core.

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Dissociation in Conditioned Dopamine Release in the Nucleus Accumbens Core and Shell in Response to Cocaine Cues and during Cocaine-Seeking Behavior in Rats

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