Nucleus accumbens long-term depression and the expression of behavioral sensitization.

@article{Brebner2005NucleusAL,
  title={Nucleus accumbens long-term depression and the expression of behavioral sensitization.},
  author={Karen Brebner and Tak Pan Wong and Lidong Liu and Yitao Liu and Paul A. Campsall and Sarah J. Gray and Lindsay Phelps and Anthony G Phillips and Yu Tian Wang},
  journal={Science},
  year={2005},
  volume={310 5752},
  pages={1340-3}
}
Drug-dependent neural plasticity related to drug addiction and schizophrenia can be modeled in animals as behavioral sensitization, which is induced by repeated noncontingent or self-administration of many drugs of abuse. Molecular mechanisms that are critical for behavioral sensitization have yet to be specified. Long-term depression (LTD) of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor (AMPAR)-mediated synaptic transmission in the brain has been proposed as a cellular… CONTINUE READING
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