Nucleus accumbens lesions modulate the effects of methylphenidate

@article{Podet2010NucleusAL,
  title={Nucleus accumbens lesions modulate the effects of methylphenidate},
  author={Adam G Podet and Min Jung Lee and Alan C. Swann and Nachum Dafny},
  journal={Brain Research Bulletin},
  year={2010},
  volume={82},
  pages={293-301}
}
The psychostimulant methylphenidate (MPD, Ritalin) is the prescribed drug of choice for treatment of ADHD. In recent years, the diagnosis rate of ADHD has increased dramatically, as have the number of MPD prescriptions. Repeated exposure to psychostimulants produces behavioral sensitization in rats, an experimental indicator of a drug's potential liability. In studies on cocaine and amphetamine, this effect has been reported to involve the nucleus accumbens (NAc), one of the nuclei belonging to… CONTINUE READING

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