Nucleus accumbens dopamine depletions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement.

@article{Salamone2001NucleusAD,
  title={Nucleus accumbens dopamine depletions make animals highly sensitive to high fixed ratio requirements but do not impair primary food reinforcement.},
  author={John D Salamone and Anna Wisniecki and Brian B. Carlson and Merc{\'e} Correa},
  journal={Neuroscience},
  year={2001},
  volume={105 4},
  pages={863-70}
}
It has been suggested that dopamine in nucleus accumbens is involved in the process of enabling organisms to overcome work-related response costs. One way of controlling work costs with operant schedules is to use fixed ratio schedules with different ratio requirements. In the present study, the effects of nucleus accumbens dopamine depletions were investigated using six schedules: fixed ratio 5, 20, 50, 100, 200, and 300. In the first three schedules the food reinforcement consisted of one 45… CONTINUE READING