Nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats

@article{Carelli2000NucleusAC,
  title={Nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats},
  author={Regina M Carelli and Stephanie G. Ijames},
  journal={Brain Research},
  year={2000},
  volume={866},
  pages={44-54}
}
Electrophysiological recording procedures were used to examine nucleus accumbens (Acb) cell firing in rats (N=13) during cocaine self-administration sessions consisting of three phases. In phase one (maintenance), each lever press resulted in an intravenous cocaine infusion (0.33 mg, 6 s) paired with a tone-houselight stimulus (20 s). Of 144 Acb cells recorded during maintenance, 39 neurons (27%) exhibited phasic firing relative to the cocaine-reinforced response [4-8]. Briefly, Acb neurons… CONTINUE READING

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