Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal

@article{Koob1989NucleusAA,
  title={Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal},
  author={George F. Koob and Tamara L Wall and Floyd E. Bloom},
  journal={Psychopharmacology},
  year={1989},
  volume={98},
  pages={530-534}
}
Previous studies from our laboratory using methylnaloxonium, a hydrophilic antagonist, showed that opiate receptors in the region of the nucleus accumbens are important for the acute reinforcing effects of heroin in non-dependent rats. A similar increased sensitivity to the response disruptive effects of intracerebrally injected methylnaloxonium in opiate dependent rats was observed in a fixed-ratio (FR) baseline of operant behaviors. These results suggest that the same opiate receptors in the… CONTINUE READING

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References

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Showing 1-10 of 17 references

A stereotaxic

  • LJ Pellegrino, AS Pellegrino, AJ Cushman
  • 1979
Highly Influential
3 Excerpts

Inability of acute or chronic thalamie, limbic, or cortical lesions to alter narcotic dependence and abstinence in rats

  • MW Adler, EB Geller, PB Beeton, PL Gildenberg
  • Dev Neurosci
  • 1978
1 Excerpt

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