Nucleus accumbens and impulsivity

@article{Baar2010NucleusAA,
  title={Nucleus accumbens and impulsivity},
  author={Koray Başar and Thibaut Sesia and Henk J. Groenewegen and Harry W. M. Steinbusch and Veerle Visser-Vandewalle and Yasin Temel},
  journal={Progress in Neurobiology},
  year={2010},
  volume={92},
  pages={533-557}
}

Figures and Tables from this paper

The Role of Dopamine Implicated in Impulsivity

Impulsivity is one of the core symptoms in a number of neuropsychiatric disorders, such as attention-deficit hyperactivity disorder (ADHD), substance abuse, and pathological gambling, however, the mechanism of dopamine in regulating impulsivity is not well established.

Nucleus accumbens core and shell inactivation differentially affects impulsive behaviours in rats

  • M. FejaL. HaynM. Koch
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2014

Impulsivity, Compulsivity, and Top-Down Cognitive Control

Oscillatory Activity in the Medial Prefrontal Cortex and Nucleus Accumbens Correlates with Impulsivity and Reward Outcome

In a subgroup of rats showing persistently high levels of impulsivity, impulsivity was associated with increased error signals following a nose-poke response, as well as reduced signals of previous trial outcome during the waiting period, providing evidence that abnormalities in the encoding of rewarding outcomes may underlie trait-like impulsive behaviour.

Brain γ‐aminobutyric acid: a neglected role in impulsivity

The lesser‐studied role of γ‐aminobutyric acid (GABA) in impulsivity is reviewed, a major target of the dopaminergic and noradrenergic systems in the prefrontal cortex and striatum, and how abnormalities in this inhibitory neurotransmitter might contribute to several forms of impulsive behaviour in humans and experimental animals are considered.

Impulsivity in heroin-dependent individuals: structural and functional abnormalities within frontostriatal circuits.

The volume of the right NAc and the RSFC strength ofright NAc-SFG could be neuroimaging biomarkers for the severity of impulsivity inHDI and could be a target for novel treatments in HDI.

Deep Brain Stimulation of the Nucleus Accumbens Core Affects Trait Impulsivity in a Baseline-Dependent Manner

NAcore DBS decreased impulsive, premature responding in HI rats under conventional conditions, and upon challenged conditions to increase impulsive responding, NA core DBS did not alter impulsivity, strongly suggest a baseline-dependent effect of DBS on impulsivity.
...

References

SHOWING 1-10 OF 311 REFERENCES

The endophenotype of impulsivity: reaching consilience through behavioral, genetic, and neuroimaging approaches.

It is proposed that by identifying intervening variables more sensitive to the effects of genetic variation, known as an endophenotype approach, will be able to overcome many of the methodological limitations that prevent a better understanding of the neurogenetic bases of behavioral inhibition.

The involvement of nucleus accumbens dopamine in appetitive and aversive motivation

  • J. Salamone
  • Psychology, Biology
    Behavioural Brain Research
  • 1994

Contrasting Roles of Basolateral Amygdala and Orbitofrontal Cortex in Impulsive Choice

This is the first time that lesions to these two structures have produced opposite behavioral effects, indicating their distinct contributions to cognition.

The Mesolimbic Dopamine Reward Circuit in Depression

The nucleus accumbens as part of a basal ganglia action selection circuit

  • S. Nicola
  • Biology, Psychology
    Psychopharmacology
  • 2006
Two hypotheses concerning the role of dopamine in these structures are proposed: that dopamine release in the dorsal striatum serves to facilitate the ability to respond appropriately to temporally predictable stimuli and that accumbens neurons participate in action selection in response to such stimuli by virtue of their direct and indirect projections to basal ganglia output nuclei.

Interactions between Serotonin and Dopamine in the Control of Impulsive Choice in Rats: Therapeutic Implications for Impulse Control Disorders

A significant role is suggested for 5-HT : DA interactions within the NAC in the control of impulsivity, and in the mechanism by which amphetamine decreases impulsive choice.

The neural basis of addiction: a pathology of motivation and choice.

Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.

Subthalamic nucleus lesions increase impulsive action and decrease impulsive choice − mediation by enhanced incentive motivation?

Findings suggest that the subthalamic nucleus may serve as a novel target for the treatment of psychological disorders characterized by deficits in behavioral control, such as drug addiction and attention deficit hyperactivity disorder.

Relationship between impulsivity, hyperactivity and working memory: a differential analysis in the rat

This novel approach shows that distinct aspects of impulsiveness and hyperactivity can be expressed based on large inter-individual differences that vary from poorly to highly adapted behaviours ones in a normal population of rats.
...