Nucleus accumbens acetylcholine and food intake: decreased muscarinic tone reduces feeding but not food-seeking.

@article{Pratt2009NucleusAA,
  title={Nucleus accumbens acetylcholine and food intake: decreased muscarinic tone reduces feeding but not food-seeking.},
  author={Wayne E. Pratt and Kaitlin Blackstone},
  journal={Behavioural brain research},
  year={2009},
  volume={198 1},
  pages={252-7}
}
Separate groups of food-deprived rats were given 2h access to food after receiving bilateral nucleus accumbens infusions of the muscarinic antagonist scopolamine methyl bromide (at 0, 1.0, and 10.0 microg/side), the M2-preferring agonist oxotremorine sesquifumarate (Oxo-S; at 0, 1.0, or 10.0 microg/side) or the M2 antagonist AFDX-116 (at 0, 0.2, or 1.0 microg/side). Injections of scopolamine or Oxo-S, but not AFDX-116, reduced food consumption across the 2h. These experiments confirm a critical… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Identification of the primary muscarinic autoreceptor subtype in rat striatum as m2 through a correlation of in vivo microdialysis and in vitro receptor binding data

  • W Billard, H Binch, 3rd, G Crosby, RD. McQuade
  • J Pharmacol Exp Ther,
  • 1995
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…