Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats

@article{Beloate2016NucleusAN,
  title={Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats},
  author={Lauren N. Beloate and P. Weems and Graham R. Casey and I. C. Webb and L. Coolen},
  journal={Neuropharmacology},
  year={2016},
  volume={101},
  pages={154-164}
}
Sexual experience in male rats followed by a period of abstinence causes sensitization to d-Amphetamine (Amph) reward, evidenced by an increased conditioned place preference (CPP) for low doses of Amph. Moreover, sexual experience induces neural plasticity within the nucleus accumbens (NAc), including induction of deltaFosB, which plays a key role in Amph reward cross-sensitization. The NMDA receptor subunit NR1 is also upregulated by mating, but the functional relevance of NMDA receptors in… Expand
mGluR5 activation in the nucleus accumbens is not essential for sexual behavior or cross-sensitization of amphetamine responses by sexual experience
TLDR
It is shown that sexual experience caused prolonged down-regulation of mGluR5 protein in the NAc, dependent on abstinence from sexual behavior, which may contribute to the cross-sensitization of amph responses by sexual experience and abstinence. Expand
Ventral Tegmental Area Dopamine Cell Activation during Male Rat Sexual Behavior Regulates Neuroplasticity and d-Amphetamine Cross-Sensitization following Sex Abstinence
TLDR
It is demonstrated that activation of ventral tegmental area dopamine neurons during sexual experience regulates cross-sensitization of amphetamine reward and contributes to increased vulnerability for drug use following loss of natural reward by causing neuroplasticity in the mesolimbic pathway during the natural reward experience. Expand
Molecular Mechanisms Underlying Sexual Experience-Dependent Neuroplasticity of the Nucleus Accumbens after in Syrian Hamsters
This study is an aims to clarify the role of delta fos-b in the reinforcement of sexual behavior in Syrian (Golden) hamsters. We used a one-way ANOVA to compare levels of delta fos-b expression fromExpand
Nucleus Accumbens Dopamine Signaling Regulates Sexual Preference for Females in Male Mice.
TLDR
A critical role for the mesolimbic dopaminergic system in governing pheromone-mediated responses and mate choice in male mice is established and signaling through the D1 receptor in the NAcc is necessary for the olfactory preference for female-soiled bedding. Expand
Effects of Sexual Experience on Psychostimulant- and Opiate-Induced Behavior and Neural Plasticity in the Mesocorticolimbic Pathway.
TLDR
The current review chapter is focused on studies that have examined the effects of sociosexual behavior in male rats on drug-induced behaviors, including changes in both psychostimulant and opiate behavior and the underlying neural mechanisms by which these effects occur. Expand
Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS)
TLDR
The authors provide a clear rationale for the adoption of genetic risk testing coupled with endorphinergic/dopamine regulation to address dysfunction across the brain reward circuitry. Expand
Drug-taking in a socio-sexual context enhances vulnerability for addiction in male rats
TLDR
Results indicate that Meth-taking in a socio- sexual context significantly enhances vulnerability for drug addiction in male rats, and this preclinical paradigm of drug self-administration concurrent with socio-sexual behavior provides a useful model for studying the underlying neurobiology of socially driven vulnerability to drug addiction. Expand
Amphetamines: Potent Recreational Drug of Abuse
Amphetamines are central nervous system (CNS) stimulants and belong to psychoactive drugs that affect chemicals in the brain, nerves and exert a constant contribution to hyperactivity and impulseExpand
Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence
TLDR
The role of glutamate in sexual behavior in rodents and non-rodent species for both males and females is reviewed and the interaction of glutamate with other neurotransmitters to impact sexual behavior is demonstrated. Expand
Influences of social reward experience on behavioral responses to drugs of abuse: Review of shared and divergent neural plasticity mechanisms for sexual reward and drugs of abuse
TLDR
An introduction and overview of the mesolimbic pathway and the influence of social reward experience on drug‐seeking behavior in rodents and the research from the laboratory on effects of sexual experience and loss of sex reward on psychostimulant and opiate reward are reviewed. Expand
...
1
2
...

References

SHOWING 1-10 OF 109 REFERENCES
Neuroplasticity in the Mesolimbic System Induced by Natural Reward and Subsequent Reward Abstinence
TLDR
Sexual experience induces functional and morphological alterations in the mesolimbic system similar to repeated exposure to psychostimulants, suggesting that some alterations in this system are common for natural and drug reward and might play a role in general reinforcement. Expand
Natural Reward Experience Alters AMPA and NMDA Receptor Distribution and Function in the Nucleus Accumbens
TLDR
Data show that sexual experience causes long-term alterations in glutamate receptor expression and function in the nucleus accumbens (NAc), suggesting common mechanisms for reinforcement of natural and drug reward. Expand
Endogenous Opioid-Induced Neuroplasticity of Dopaminergic Neurons in the Ventral Tegmental Area Influences Natural and Opiate Reward
TLDR
It is demonstrated that endogenous opioids during mating induce neural plasticity in VTA dopamine neurons that appear critical for morphine reward and long-term memory for natural reward behavior. Expand
Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters
TLDR
The data indicate that female sexual behavior can activate neurons in the nucleus accumbens and that sexual experience can cross-sensitize neuronal responses to amphetamine, and provide additional evidence for functional differences between the shell and core of the nucleus AccumbENS and across its anteroposterior axis. Expand
NR2B subunit of NMDA receptor at nucleus accumbens is involved in morphine rewarding effect by siRNA study.
TLDR
Findings suggest that the NR2B subunit of NMDA receptors at the NAc is involved in morphine-induced rewarding effect and may not be through directly interacting with dopamine neurons. Expand
Involvement of amygdala dopamine- and nucleus accumbens NMDA-receptors in ethanol-seeking behavior in mice
TLDR
The present findings suggest that expression of the ethanol-conditioned response depends upon amygdala dopamine and accumbens NMDA receptors, the first studies in any species to show a role for amygdala dopamine receptors and the first study in mice to implicate accumben NMDA receptor receptors in ethanol-induced conditioned effects. Expand
ΔFosB in the nucleus accumbens is critical for reinforcing effects of sexual reward
TLDR
A critical role for ΔFosB expression in the NAc for the reinforcing effects of sexual behavior and sexual experience‐induced facilitation of sexual performance is supported. Expand
D1 Dopamine Receptors Modulate ΔFosB Induction in Rat Striatum after Intermittent Morphine Administration
TLDR
Results demonstrate that morphine-induced ΔFosB up- regulation in the striatum, but not in the frontal cortex, is modulated by D1 dopamine receptors, suggesting that the mechanisms involved in the up-regulation of these chronic Fras by morphine is brain region-specific. Expand
Natural and Drug Rewards Act on Common Neural Plasticity Mechanisms with ΔFosB as a Key Mediator
TLDR
It is demonstrated that sexual experience in male rats when followed by short or prolonged periods of loss of sex reward causes enhanced amphetamine reward, indicated by sensitized conditioned place preference for low-dose amphetamine, and that this increased vulnerability is mediated by ΔFosB and its downstream transcriptional targets. Expand
Effect of glutamate receptor antagonists microinjected into the nucleus accumbens on place aversion induced by naloxone in single-dose, morphine-treated rats.
TLDR
It is suggested that glutamate receptors in the nucleus accumbens play a key role in the motivational component of withdrawal during acute morphine dependence. Expand
...
1
2
3
4
5
...