Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats

  title={Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats},
  author={Lauren N Beloate and Peyton W. Weems and Graham R. Casey and Ian C. Webb and Lique M Coolen},

Ventral Tegmental Area Dopamine Cell Activation during Male Rat Sexual Behavior Regulates Neuroplasticity and d-Amphetamine Cross-Sensitization following Sex Abstinence

It is demonstrated that activation of ventral tegmental area dopamine neurons during sexual experience regulates cross-sensitization of amphetamine reward and contributes to increased vulnerability for drug use following loss of natural reward by causing neuroplasticity in the mesolimbic pathway during the natural reward experience.

Molecular Mechanisms Underlying Sexual Experience-Dependent Neuroplasticity of the Nucleus Accumbens after in Syrian Hamsters

It is found that a significantly greater amount of delta fos-b expression in the NAc is found in sexually experienced hamsters (both males and females) compared to naïve animals, and there was no difference between sexually experienced males and Female in overall delta fOS-bexpression in theNAc.

Drug-taking in a socio-sexual context enhances vulnerability for addiction in male rats

Results indicate that Meth-taking in a socio- sexual context significantly enhances vulnerability for drug addiction in male rats, and this preclinical paradigm of drug self-administration concurrent with socio-sexual behavior provides a useful model for studying the underlying neurobiology of socially driven vulnerability to drug addiction.

Amphetamines: Potent Recreational Drug of Abuse

The functions of the amphetamines as recreation drug of abuse are explored, considered by compulsive drug-seeking and drug use and a phenomenon notorious as amphetamine psychosis.

Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence

The role of glutamate in sexual behavior in rodents and non-rodent species for both males and females is reviewed and the interaction of glutamate with other neurotransmitters to impact sexual behavior is demonstrated.



Natural Reward Experience Alters AMPA and NMDA Receptor Distribution and Function in the Nucleus Accumbens

Data show that sexual experience causes long-term alterations in glutamate receptor expression and function in the nucleus accumbens (NAc), suggesting common mechanisms for reinforcement of natural and drug reward.

Sexual Behavior Induction of c-Fos in the Nucleus Accumbens and Amphetamine-Stimulated Locomotor Activity Are Sensitized by Previous Sexual Experience in Female Syrian Hamsters

The data indicate that female sexual behavior can activate neurons in the nucleus accumbens and that sexual experience can cross-sensitize neuronal responses to amphetamine, and provide additional evidence for functional differences between the shell and core of the nucleus AccumbENS and across its anteroposterior axis.

Involvement of amygdala dopamine- and nucleus accumbens NMDA-receptors in ethanol-seeking behavior in mice

The present findings suggest that expression of the ethanol-conditioned response depends upon amygdala dopamine and accumbens NMDA receptors, the first studies in any species to show a role for amygdala dopamine receptors and the first study in mice to implicate accumben NMDA receptor receptors in ethanol-induced conditioned effects.

ΔFosB in the nucleus accumbens is critical for reinforcing effects of sexual reward

A critical role for ΔFosB expression in the NAc for the reinforcing effects of sexual behavior and sexual experience‐induced facilitation of sexual performance is supported.

D1 Dopamine Receptors Modulate ΔFosB Induction in Rat Striatum after Intermittent Morphine Administration

Results demonstrate that morphine-induced ΔFosB up- regulation in the striatum, but not in the frontal cortex, is modulated by D1 dopamine receptors, suggesting that the mechanisms involved in the up-regulation of these chronic Fras by morphine is brain region-specific.

Natural and Drug Rewards Act on Common Neural Plasticity Mechanisms with ΔFosB as a Key Mediator

It is demonstrated that sexual experience in male rats when followed by short or prolonged periods of loss of sex reward causes enhanced amphetamine reward, indicated by sensitized conditioned place preference for low-dose amphetamine, and that this increased vulnerability is mediated by ΔFosB and its downstream transcriptional targets.