Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats

@article{Beloate2016NucleusAN,
  title={Nucleus accumbens NMDA receptor activation regulates amphetamine cross-sensitization and deltaFosB expression following sexual experience in male rats},
  author={Lauren N. Beloate and P. Weems and G. Casey and I. C. Webb and L. Coolen},
  journal={Neuropharmacology},
  year={2016},
  volume={101},
  pages={154-164}
}
  • Lauren N. Beloate, P. Weems, +2 authors L. Coolen
  • Published 2016
  • Psychology, Medicine
  • Neuropharmacology
  • Sexual experience in male rats followed by a period of abstinence causes sensitization to d-Amphetamine (Amph) reward, evidenced by an increased conditioned place preference (CPP) for low doses of Amph. Moreover, sexual experience induces neural plasticity within the nucleus accumbens (NAc), including induction of deltaFosB, which plays a key role in Amph reward cross-sensitization. The NMDA receptor subunit NR1 is also upregulated by mating, but the functional relevance of NMDA receptors in… CONTINUE READING
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    Paper Mentions

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