Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma.

@article{Bowers2008NucleusAA,
  title={Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma.},
  author={Michael Scott Bowers and Frederic Woodward Hopf and Jonathan K. Chou and Anitra M. Guillory and Shao-Ju Chang and Patricia H Janak and Antonello Bonci and Ivan Berkeley Diamond},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 34},
  pages={
          12533-8
        }
}
Approximately 90% of alcoholics relapse within 4 years, in part because of an enhanced motivation to seek alcohol (EtOH). A novel G protein modulator (Gpsm1/AGS3) was up-regulated in the rat nucleus accumbens core (NAcore) but not in other limbic nuclei during abstinence from operant EtOH self-administration. Furthermore, NAcore AGS3 knockdown reduced EtOH seeking to pre-abstinence levels in a novel rat model of compulsive, human EtOH seeking. AGS3 can both inhibit G protein G i alpha-mediated… CONTINUE READING
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