Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression

@article{Bewernick2010NucleusAD,
  title={Nucleus Accumbens Deep Brain Stimulation Decreases Ratings of Depression and Anxiety in Treatment-Resistant Depression},
  author={Bettina H. Bewernick and Ren{\'e} Hurlemann and Andreas Matusch and Sarah Kayser and Christiane Grubert and Barbara Hadrysiewicz and Nikolai Axmacher and Matthias R. Lemke and D{\'e}irdre Cooper-Mahkorn and Michael X. Cohen and Holger Brockmann and Doris Lenartz and Volker Sturm and Thomas E. Schlaepfer},
  journal={Biological Psychiatry},
  year={2010},
  volume={67},
  pages={110-116}
}
BACKGROUND While most patients with depression respond to combinations of pharmacotherapy, psychotherapy, and electroconvulsive therapy (ECT), there are patients requiring other treatments. Deep brain stimulation (DBS) allows modulation of brain regions that are dysfunctional in depression. Since anhedonia is a feature of depression and there is evidence of dysfunction of the reward system, DBS to the nucleus accumbens (NAcc) might be promising. METHODS Ten patients suffering from very… Expand

Paper Mentions

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