Nucleotidyl cyclase activity of soluble guanylyl cyclase in intact cells.

Abstract

Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and generates the second messenger cyclic GMP (cGMP). Recently, purified sGC α1β1 has been shown to additionally generate the cyclic pyrimidine nucleotides cCMP and cUMP. However, since cyclic pyrimidine nucleotide formation occurred only the presence of Mn(2+) but not Mg(2+), the… (More)
DOI: 10.1016/j.bbrc.2013.12.108

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