Nucleotides modulate the low affinity binding sites for [3H]glibenclamide in the rat brain.

@article{Zini1993NucleotidesMT,
  title={Nucleotides modulate the low affinity binding sites for [3H]glibenclamide in the rat brain.},
  author={S M Zini and Roland Zini and Yehezkel Ben-Ari},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={264 2},
  pages={701-8}
}
Receptors for hypoglycemic sulfonylureas, such as glibenclamide, are commonly linked to the activity of ATP-sensitive K+ channels (K-ATP). High and low affinity binding sites for glibenclamide were described previously in numerous tissues. High affinity binding sites have been thought to be responsible of the modulation of K-ATP, but new evidences suggest that low affinity ones could also regulate these channels. In order to clarify the properties of the two binding sites, with respect to their… CONTINUE READING