Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: a hybrid case-parent triad and case-control study.

@article{Hussain2013NucleotideVI,
  title={Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: a hybrid case-parent triad and case-control study.},
  author={Shehnaz K. Hussain and M M Madeleine and Lisa Godefroy Johnson and Qin Du and Denise A. Galloway and Janet R. Daling and Mari Malkki and Effie W. Petersdorf and Stephen M Schwartz},
  journal={International journal of cancer},
  year={2013},
  volume={133 1},
  pages={201-13}
}
Given the important role of cell mediated immunity in viral clearance and control of premalignant lesions, we hypothesize that variation in the IL-12/IL-10 cytokine and cytokine receptor genes may influence cervical and vulvar cancer risk. We evaluated 76 tagSNPs from seven candidate genes (IL-10, IL-12A, IL-12B, IL-10RA, IL-10RB, IL-12RB1, and IL12RB2) in case-parent sets (n=43 cervical squamous cell carcinoma (SCC), n=96 cervical adenocarcinoma, n=53 vulvar SCC), additional cases (n=356… CONTINUE READING

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