Nucleotide variation and haplotype diversity in a 10-kb noncoding region in three continental human populations.

@article{Zhao2006NucleotideVA,
  title={Nucleotide variation and haplotype diversity in a 10-kb noncoding region in three continental human populations.},
  author={Zhongming Zhao and Ning Yu and Yun-Xin Fu and Wen-Hsiung Li},
  journal={Genetics},
  year={2006},
  volume={174 1},
  pages={399-409}
}
Noncoding regions are usually less subject to natural selection than coding regions and so may be more useful for studying human evolution. The recent surveys of worldwide DNA variation in four 10-kb noncoding regions revealed many interesting but also some incongruent patterns. Here we studied another 10-kb noncoding region, which is in 6p22. Sixty-six single-nucleotide polymorphisms were found among the 122 worldwide human sequences, resulting in 46 genotypes, from which 48 haplotypes were… CONTINUE READING

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The averaged mutation rate (2.01 × 10 -4 per sequence per generation) estimated by humanchimpanzee (6 Myr) and human-gorilla (8 Myr) was used

  • The averaged mutation rate (2.01 × 10 -4 per…

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