Nucleotide variability at G6pd and the signature of malarial selection in humans.

  title={Nucleotide variability at G6pd and the signature of malarial selection in humans.},
  author={Matthew A. Saunders and Michael F. Hammer and Michael W Nachman},
  volume={162 4},
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans. Deficiency alleles for this X-linked disorder are geographically correlated with historical patterns of malaria, and the most common deficiency allele in Africa (G6PD A-) has been shown to confer some resistance to malaria in both hemizygous males and heterozygous females. We studied DNA sequence variation in 5.1 kb of G6pd from 47 individuals representing a worldwide sample to examine the impact of… CONTINUE READING
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Hitchhiking under positive Darwinian and genetic diseases in Africans and African - Americans

  • C.-I Wu
  • Proc . selection . Genetics Acad . Sci . USA
  • 2000
Highly Influential
3 Excerpts

Evidence for balancing selectionGlucose - 6 - phosphate dehydrogenase deficiency inhibits in vitro from nucleotide sequence analyses of human G 6 PD . Am . J . Hum . growth of Plasmodium falciparum

  • A. Othman, M. Town, A. Nathwani, A. W. Snow, D. Kwiatkowski
  • Proc . Natl . Acad . Sci . USA 80 : Genet .
  • 2002

A highly variable segment Oxf

  • R. R. Hudson
  • Surv . Evol . Biol .
  • 2001

Microsatellite variationdogene with increased variation due to balancing selection at and recombination rate in the human genome

  • K. A. Mather, C. Ober, M. W. Nachman
  • Hum . Genet .
  • 2000

Commentary : malariaSequence variation in the human angiotensin converting enzyme . control in the 1990 s . Bull . WHO

  • P. W. Li
  • 1998

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