Corpus ID: 9513427

Nucleotide variability at G6pd and the signature of malarial selection in humans.

@article{Saunders2002NucleotideVA,
  title={Nucleotide variability at G6pd and the signature of malarial selection in humans.},
  author={M. Saunders and M. Hammer and M. Nachman},
  journal={Genetics},
  year={2002},
  volume={162 4},
  pages={
          1849-61
        }
}
  • M. Saunders, M. Hammer, M. Nachman
  • Published 2002
  • Medicine, Biology
  • Genetics
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans. Deficiency alleles for this X-linked disorder are geographically correlated with historical patterns of malaria, and the most common deficiency allele in Africa (G6PD A-) has been shown to confer some resistance to malaria in both hemizygous males and heterozygous females. We studied DNA sequence variation in 5.1 kb of G6pd from 47 individuals representing a worldwide sample to examine the impact of… CONTINUE READING
    Population genetics of malaria resistance in humans
    • 179
    • Open Access
    Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia
    • 34
    • Highly Influenced
    • Open Access

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 77 REFERENCES
    Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Alleles That Confer Malarial Resistance
    • 565
    • Highly Influential
    • Open Access
    Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria
    • 518
    • Highly Influential
    DNA sequence variation in a non-coding region of low recombination on the human X chromosome
    • 235
    • Open Access
    Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22.
    • 150
    • Open Access
    Global Patterns of Linkage Disequilibrium at the CD4 Locus and Modern Human Origins
    • 565
    • Open Access
    Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase.
    • 466
    • Open Access