Corpus ID: 9513427

Nucleotide variability at G6pd and the signature of malarial selection in humans.

  title={Nucleotide variability at G6pd and the signature of malarial selection in humans.},
  author={M. Saunders and M. Hammer and M. Nachman},
  volume={162 4},
  • M. Saunders, M. Hammer, M. Nachman
  • Published 2002
  • Medicine, Biology
  • Genetics
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans. Deficiency alleles for this X-linked disorder are geographically correlated with historical patterns of malaria, and the most common deficiency allele in Africa (G6PD A-) has been shown to confer some resistance to malaria in both hemizygous males and heterozygous females. We studied DNA sequence variation in 5.1 kb of G6pd from 47 individuals representing a worldwide sample to examine the impact of… CONTINUE READING
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