Nucleotide synthetase ribozymes may have emerged first in the RNA world.

@article{Ma2007NucleotideSR,
  title={Nucleotide synthetase ribozymes may have emerged first in the RNA world.},
  author={Wentao Ma and Chunwu Yu and Wentao Zhang and Jiming Hu},
  journal={RNA},
  year={2007},
  volume={13 11},
  pages={2012-9}
}
Though the "RNA world" hypothesis has gained a central role in ideas concerning the origin of life, the scenario concerning its emergence remains uncertain. It has been speculated that the first scene may have been the emergence of a template-dependent RNA synthetase ribozyme, which catalyzed its own replication: thus, "RNA replicase." However, the speculation remains uncertain, primarily because of the large sequence length requirement of such a replicase and the lack of a convincing mechanism… CONTINUE READING
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