Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.

@article{Hughes1989NucleotideSA,
  title={Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.},
  author={Austin L. Hughes and Masatoshi Nei},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 3},
  pages={958-62}
}
To study the mechanism of maintenance of polymorphism at major histocompatibility complex (MHC) loci, synonymous and nonsynonymous (amino acid-altering) nucleotide substitutions in the putative antigen-recognition site (included in the first domain of the MHC molecule) and other regions of human and mouse class II genes were examined. In the putative antigen-recognition site, the rate of nonsynonymous substitution was found to exceed that of synonymous substitution, whereas in the second domain… CONTINUE READING
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