Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta.

@article{Greenfield1983NucleotideSO,
  title={Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta.},
  author={Lawrence I Greenfield and Michael Bjorn and Glenn Thomas Horn and Daniel Mart{\'i}nez Fong and Gregory A. Buck and Robert J. Collier and Donald A. Kaplan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1983},
  volume={80 22},
  pages={
          6853-7
        }
}
A 1,942-base-pair DNA segment encoding the structural gene for diphtheria toxin was sequenced, and the primary structure of the toxin was deduced. Restriction enzyme fragments corresponding to nontoxic or hypotoxic peptides of the toxin were isolated from corynebacteriophage beta and cloned into Escherichia coli on plasmid pBR322, and the sequence was determined. The mature toxin molecule deduced from the sequence has 535 amino acid residues and a molecular weight of 58,342. The deduced… CONTINUE READING
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