Nucleotide sequence of the human coronavirus 229E RNA polymerase locus.

@article{Herold1993NucleotideSO,
  title={Nucleotide sequence of the human coronavirus 229E RNA polymerase locus.},
  author={Johannes Herold and Tobias Raabe and B Schelle-Prinz and Stuart G. Siddell},
  journal={Virology},
  year={1993},
  volume={195 2},
  pages={680-91}
}
The nucleotide sequence of the human coronavirus 229E (HCV 229E) RNA polymerase gene and the 5' region of the genome has been determined. The polymerase gene is comprised of two large open reading frames, ORF1a and ORF1b, that contain 4086 and 2687 codons, respectively. ORF1b overlaps ORF1a by 43 bases in the (-1) reading frame. The in vitro translation of SP6 transcripts which include HCV 229E sequences encompassing the ORF1a/ORF1b junction show that expression of ORF1b can be mediated by… CONTINUE READING
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