Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation.

@article{OHara1987NucleotideSO,
  title={Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation.},
  author={P. J. O'Hara and F. J. Grant and Betty Haldeman and C L Gray and Maggie Insley and F S Hagen and Merritt J. Murray},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 15},
  pages={5158-62}
}
Activated factor VII (factor VIIa) is a vitamin K-dependent plasma serine protease that participates in a cascade of reactions leading to the coagulation of blood. Two overlapping genomic clones containing sequences encoding human factor VII were isolated and characterized. The complete sequence of the gene was determined and found to span about 12.8 kilobases. The mRNA for factor VII as demonstrated by cDNA cloning is polyadenylylated at multiple sites but contains only one AAUAAA poly(A… CONTINUE READING

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