Nucleotide sequence of the full length cDNA encoding for human type II procollagen.

Abstract

Type II collagen is a homotrimeric molecule composed of three identical al(II) collagen chains that are synthesized as precursor procollagens with aminoand carboxy-terminal propeptides that are removed extracellularly. Mutati'ons in the ol(II) .chain result in disproportionate dwarfing disorders in the spectrum of skeletal dysplasias,' Hitherto, only the… (More)

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