Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.

@article{Sutcliffe1978NucleotideSO,
  title={Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.},
  author={J. Gregor Sutcliffe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1978},
  volume={75 8},
  pages={3737-41}
}
I have determined the nucleotide sequence of the ampicillin resistance gene of pBR322, an Escherichia coli plasmid that encodes a penicillin beta-lactamase. This gene codes for a protein of 286 amino acid residues. The first 23 amino acids presumably form a signal for secretion, because they do not appear in the mature enzyme, whose partial amino acid sequence has been determined independently. 

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