Nucleotide sequence of immunoglobulin heavy chain joining segments between translocated VH and t constant region genes ( p mRNA / Cp gene / active VH gene / JH sequences / antibody diversity

Abstract

To investigate the mechanism of recombination of immunoglobulin heavy chain variable and constant region genes, we ave determined the nucleotide sequence of a large portion of the recombination region between an active Cp gene and its associated VH gene, isolated from an IgM-secreting mouse plasmacytoma, HPC76. By comparison with the sequence of the p mRNA… (More)

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