Nucleotide sequence heterogeneity of an RNA phage population.

  title={Nucleotide sequence heterogeneity of an RNA phage population.},
  author={Esteban Domingo and Diane Sabo and T. Taniguchi and Charles Weissmann},
  volume={13 4},
The nucleotide sequence of 32P-RNA from Q beta phage clones was sampled by two-dimensional polyacrylamide gel electrophoresis of the RNAase T1-resistant oligonucleotides (T1 fingerprinting). About 15% of the clones derived from a multiply passaged Q beta population showed fingerprint patterns which deviated from that of the RNA from the total population. All deviations examined could be attributed to one and, less frequently, to two or more nucleotide transitions. Since the fingerprinting… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 16 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 138 extracted citations

Similar Papers

Loading similar papers…