Nucleotide sequence heterogeneity of an RNA phage population

@article{Domingo1978NucleotideSH,
  title={Nucleotide sequence heterogeneity of an RNA phage population},
  author={E. Domingo and D. Sabo and T. Taniguchi and C. Weissmann},
  journal={Cell},
  year={1978},
  volume={13},
  pages={735-744}
}
The nucleotide sequence of 32P-RNA from Q beta phage clones was sampled by two-dimensional polyacrylamide gel electrophoresis of the RNAase T1-resistant oligonucleotides (T1 fingerprinting). About 15% of the clones derived from a multiply passaged Q beta population showed fingerprint patterns which deviated from that of the RNA from the total population. All deviations examined could be attributed to one and, less frequently, to two or more nucleotide transitions. Since the fingerprinting… Expand
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