Nucleotide sequence and phylogeny of SHV-2 beta-lactamase.

  title={Nucleotide sequence and phylogeny of SHV-2 beta-lactamase.},
  author={Ann Huletsky and France Couture and Roger C. L{\'e}vesque},
  journal={Antimicrobial agents and chemotherapy},
  volume={34 9},
We determined the nucleotide sequence of the blaSHV-2(pBP60-1) gene from Klebsiella ozaenae which confers resistance to broad-spectrum cephalosporins. The structural gene encodes a polypeptide product of 286 amino acids, and the estimated molecular weight of the mature protein is 28,900. Amino acid sequence comparison of the SHV-2pBP60-1 enzyme with all known class A beta-lactamases and homology studies showed that the residues were highly conserved. Furthermore, SHV-2pBP60-1 was clearly… CONTINUE READING
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